{"id":181,"date":"2023-09-17T18:18:34","date_gmt":"2023-09-17T18:18:34","guid":{"rendered":"https:\/\/wagnerlabs.maximilianfalter.de\/?page_id=181"},"modified":"2024-03-11T11:55:38","modified_gmt":"2024-03-11T11:55:38","slug":"hfvac3","status":"publish","type":"page","link":"https:\/\/wagner-lab.de\/?page_id=181","title":{"rendered":"HFVac3"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"181\" class=\"elementor elementor-181\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2402c4b6 e-flex e-con-boxed e-con e-parent\" data-id=\"2402c4b6\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3c2b10f2 e-con-full e-flex e-con e-child\" data-id=\"3c2b10f2\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5630dad4 elementor-widget elementor-widget-heading\" data-id=\"5630dad4\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">HFVac3<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-687011fb elementor-widget elementor-widget-text-editor\" data-id=\"687011fb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"bodytext\"><strong>Funding: Innovate UK<\/strong><br \/><strong>Title:<\/strong> <strong>Clinical trial of a DIOS Trivalent Haemorrhagic Fever Vaccine<\/strong><\/p><p>The HFVac3-project is based on the predecessor projects EVAC and Tri-LEMvac that also were funded by Innovate UK. Within the EVAC project, a streamlined process for vaccine generation starting with in silico design of antigen sequences, over the generation of delivery vectors (DNA, adenovirus, vaccinia virus) and rapid testing for immunogenicity in small animal models (mice and guinea pigs) \u2013 all steps to be completed within one year \u2013 had been developed.<\/p><div id=\"moreText\"><p>In a parallel track within the Tri-LEMvac project, proof-of-concept for immunogenicity and (in part) efficacy of such vaccine candidates against three different haemorrhagic fever viruses (Lassa, Ebola, and Marburg virus) has been obtained.<br \/>Now, the outcomes of these two projects will be joined to come up with a clinical vaccine candidate and start a phase I clinical trial to assess the safety and immunogenicity of this vaccine candidate addressing the three viral diseases.<\/p><p>The Wagner lab contribution to the project encompasses the generation and characterization of the MVA vaccine candidate vector suitable for GMP manufacturing.<\/p><\/div><p><button id=\"readMoreBtn\">Read more<\/button><\/p><p><strong>Project partners:<\/strong><br \/>Prof. Jonathan Heeney (University of Cambridge) &#8211; project co-ordinator,<br \/>Prof. Ralf Wagner (University of Regensburg, Institute for Medical Microbiology and Hygiene, Molecular Microbiology (Virology),<br \/>DIOSynVax Ltd.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d6d5480 e-con-full e-flex e-con e-child\" data-id=\"d6d5480\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3ee0a3d elementor-widget elementor-widget-spacer\" data-id=\"3ee0a3d\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3b7f4f79 elementor-widget elementor-widget-image\" data-id=\"3b7f4f79\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"600\" height=\"159\" src=\"https:\/\/wagner-lab.de\/wp-content\/uploads\/2024\/02\/1.png\" class=\"attachment-large size-large wp-image-2323\" alt=\"\" srcset=\"https:\/\/wagner-lab.de\/wp-content\/uploads\/2024\/02\/1.png 600w, https:\/\/wagner-lab.de\/wp-content\/uploads\/2024\/02\/1-300x80.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>HFVac3 Funding: Innovate UKTitle: Clinical trial of a DIOS Trivalent Haemorrhagic Fever Vaccine The HFVac3-project is based on the predecessor projects EVAC and Tri-LEMvac that also were funded by Innovate UK. Within the EVAC project, a streamlined process for vaccine generation starting with in silico design of antigen sequences, over the generation of delivery vectors [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-181","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>HFVac3<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wagner-lab.de\/?page_id=181\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HFVac3\" \/>\n<meta property=\"og:description\" content=\"HFVac3 Funding: Innovate UKTitle: Clinical trial of a DIOS Trivalent Haemorrhagic Fever Vaccine The HFVac3-project is based on the predecessor projects EVAC and Tri-LEMvac that also were funded by Innovate UK. 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